- POLR2A
Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, also known as POLR2A, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [cite web | title = Entrez Gene: POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5430| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24–7 |year= 1998 |pmid= 9570510 |doi=
*cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447–9 |year= 1998 |pmid= 9651670 |doi=
*cite journal | author=Romano G, Kasten M, De Falco G, "et al." |title=Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. |journal=J. Cell. Biochem. |volume=75 |issue= 3 |pages= 357–68 |year= 2000 |pmid= 10536359 |doi=
*cite journal | author=Szentirmay MN, Sawadogo M |title=Spatial organization of RNA polymerase II transcription in the nucleus. |journal=Nucleic Acids Res. |volume=28 |issue= 10 |pages= 2019–25 |year= 2000 |pmid= 10773068 |doi=
*cite journal | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175–81 |year= 2002 |pmid= 11547919 |doi=PBB_Controls
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