3alpha(or 20beta)-hydroxysteroid dehydrogenase

In enzymology, a 3alpha(or 20beta)-hydroxysteroid dehydrogenase (EC number|1.1.1.53) is an enzyme that catalyzes the chemical reaction

:androstan-3alpha,17beta-diol + NAD⁺ $ightleftharpoons$ 17beta-hydroxyandrostan-3-one + NADH + H⁺

Thus, the two substrates of this enzyme are androstan-3alpha,17beta-diol and NAD⁺, whereas its 3 products are 17beta-hydroxyandrostan-3-one, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase. Other names in common use include cortisone reductase, (R)-20-hydroxysteroid dehydrogenase, dehydrogenase, 20beta-hydroxy steroid, Delta4-3-ketosteroid hydrogenase, 20beta-hydroxysteroid dehydrogenase, 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase, NADH-20beta-hydroxysteroid dehydrogenase, and 20beta-HSD. This enzyme participates in bile acid biosynthesis and c21-steroid hormone metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1HDC, PDB link|1N5D, PDB link|1NFF, PDB link|1NFQ, PDB link|1NFR, and PDB link|2HSD.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-42-6."

Gene Ontology (GO) codes