3alpha-hydroxycholanate dehydrogenase

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC number|1.1.1.52) is an enzyme that catalyzes the chemical reaction

:3alpha-hydroxy-5beta-cholanate + NAD⁺ $ightleftharpoons$ 3-oxo-5beta-cholanate + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD⁺, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1IHI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-57-3."

Gene Ontology (GO) codes