2-(R)-hydroxypropyl-CoM dehydrogenase

In enzymology, a 2-(R)-hydroxypropyl-CoM dehydrogenase (EC number|1.1.1.268) is an enzyme that catalyzes the chemical reaction

:2-(R)-hydroxypropyl-CoM + NAD⁺ $ightleftharpoons$ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(R)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2- [2-(R)-hydroxypropylthio] ethanesulfonate:NAD+ oxidoreductase. This enzyme is also called 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2CFC.

References

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External links

Gene Ontology (GO) codes