Pangamic acid

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ImageFile=Pangamic acid.pngImageSize=350px
IUPACName=6-(2-Dimethylamino-acetoxy)- 2,3,4,5-tetrahydroxy-hexanoic acid
OtherNames=Vitamin B15
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CASNo=20858-86-0
SMILES=OC( [C@H] (O) [C@@H] (O) [C@H] (O) [C@H] (O)COC(CN(C)C)=O)=O
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Formula=C₁₀H₁₉NO₈
MolarMass=281.26
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Pangamic acid is an ester derived from gluconic acid and dimethylglycine. [Recent data on the structure of pangamic acid (vitamin B15). Telegdy Kovats, Laszlo; Berndorfer-Kraszner, Eva; Juhasz, Agnes; Gabor, Tamas. "Acta Alimentaria Academiae Scientiarum Hungaricae" (1976), 5(3), 281-8.] It was first isolated by Ernst T. Krebs from apricot kernels, [KREBS E T Sr; KREBS E T Jr; BEARD H H; MALIN R; HARRIS A T; BARTLETT C L Pangamic acid sodium: a newly isolated crystalline water-soluble factor; a preliminary report. International record of medicine and general practice clinics (1951), 164(1), 18-23.] and has since been identified in some foods such as pulses. [Singh, Jagdev; Handa, Mrs. Geeta; Nandi, L. N.; Manavalan, R.; Atal, C. K. D-Gluconodimethylaminoacetic acid from natural sources. "Indian Drugs" (1983), 20(5), 185-9.] Also found in rice bran & apricot kernels.

Pangamic acid is also known as "vitamin B₁₅", but it is not widely accepted as a vitamin for it has not been shown to be essential in the human diet, and a deficiency in consumption of pangamic acid is not known to be associated with any disease. [" [http://www.healthy.net/scr/article.asp?ID=1925 Vitamin B15 - Pangamic Acid] ", Elson M. Haas M.D.]

The calcium salt of pangamic acid, calcium pangamate, is used as a mineral supplement. Like thiamine, pangamic acid causes a temporary drop in blood pressure lasting for about 20 minutes.

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