Provascular anticancer therapy

Provascular anticancer therapy is a strategy that exploits the differential reactivity of mature tumor blood vessels to increase the efficacy of conventional anticancer treatments (such as radiotherapy and chemotherapy). [Feron O. Targeting the tumor vascular compartment to improve conventional cancer therapy. "Trends Pharmacol. Sci." 2004;25:536-542] Based on the identification of an altered regulation of vascular reactivity in tumors, the provascular approach aims at selectively inducing a transient dilation of functional tumor microvessels, leading to increased tumor perfusion, increased drug delivery and increased tumor oxygenation and radiosensitivity.

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