Indo-1

Indo-1

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ImageFile = Indo-1.png ImageSize = 250px
IUPACName = 2- [4-(bis(carboxymethyl)amino)-3- [2- [2-(bis(carboxymethyl)amino)-5-methylphenoxy] ethoxy] phenyl] -1H-indole-6-carboxylic acid
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OtherNames = Indo-1
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CASNo = 96314-96-4
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PubChem = 105060
SMILES = CC1=CC(=C(C=C1)N(CC(=O)O)CC(=O)O)OCCOC2=C(C=CC(=C2)C3=CC4=C(N3)C=C(C=C4)C(=O)O)N(CC(=O)O)CC(=O)O
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Formula = C32H31N3O12
MolarMass = 649.60 g/mol
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Indo-1 is a popular calcium indicator similar to Fura-2. In contrast to Fura-2, Indo-1 has a dual emissions peak. The main emission peak in calcium free solution is 475 nm while in the presence of calcium the the emission is shifted to 400 nm. It is widely used in flow cytometry.The penta potassium salt is commercially available and preferred to the free acid because of its higher solubility in water. While Indo-1 is not cell permeable the penta acetoxymethyl ester Indo-1 AM enters the cell where it is cleaved by intracellular esterases to Indo-1.The synthesis and properties of Indo-1 were presented in 1985 by the group of Roger Y Tsien.cite journal
author=Grynkiewicz G, Poenie M, Tsien RY
title=A new generation of Ca2+ indicators with greatly improved fluorescence properties
journal=J. Biol. Chem.
volume=260
issue=6
pages=3440–50
year=1985
pmid=3838314
doi=]

ee also

External links

* [https://catalog.invitrogen.com/index.cfm?fuseaction=viewCatalog.viewProductDetails&productDescription=7876 Indo-1 product description]

References

* [http://www.lymphozyten.de/docs/methods_ca_jenne_2003.pdf Lars Jenne - Intracellular Calcium Release]


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  • indo- — ♦ Élément, du lat. Indus « de l Inde » : indo aryen, indo iranien. ⇒INDO , élém. de compos. Premier élém. de compos. tiré du lat. Indus « de l Inde », entrant dans la formation de qq. subst. et adj., notamment dans les domaines ethnol. et ling.;… …   Encyclopédie Universelle

  • indo — europeánă (limba) s. f. (sil. e u , pea ), g. d. art. indo europénei Trimis de siveco, 10.08.2004. Sursa: Dicţionar ortografic  indo germánic adj. m. germanic Trimis de siveco, 10.08.2004. Sursa: Dicţionar ortografic  INDO : indo EUROP//EÁN1… …   Dicționar Român

  • Indo — may refer to: * Indo , prefix indicating India or the Indian subcontinent ** Examples of words with Indo prefix: Indology, Indologist, Indomania, Indophobia, Indophile, and Indo European * Indo people, people of mixed European and Indonesian… …   Wikipedia

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  • Indo- — [in′dō] [Gr < Indos: see INDIA] combining form 1. India or the East Indies 2. India and 3. Indo European [Indo Hittite] …   English World dictionary

  • Indo- — [ındəu US dou] prefix [in nouns and adjectives] Indian and something else ▪ Indo European languages …   Dictionary of contemporary English

  • indo- — elem. de comp. Entra na formação de palavras compostas com a significação de índio, relativo à Índia ou aos índios (ex.: indo europeu). [É seguido de hífen quando se liga a elemento morfologicamente individualizado.]   ‣ Etimologia: Índia,… …   Dicionário da Língua Portuguesa

  • Indo- — In do [From L. Indus East Indian.] A prefix signifying Indian (i. e., East Indian); of or pertaining of India. [1913 Webster] …   The Collaborative International Dictionary of English

  • INDO — stands for Intermediate Neglect of Differential Overlap. It is a semi empirical quantum chemistry method that is a development of the complete neglect of diiferential overlap (CNDO/2) method introduced by John Pople. Like CNDO/2 it uses zero… …   Wikipedia

  • INDO — [Abk. für engl. intermediate neglect of differential overlap = mittelstarke Vernachlässigung der differentiellen Überlappung]: ein sog. Allvalenz u. Allelektronen LCAOMO Verfahren der MO Theorie, das bestimmte Vereinfachungen einführt …   Universal-Lexikon

  • indo- — [dal lat. Indus, gr. Indos indiano ]. Primo elemento di parole composte, col sign. di indiano (dell India) o che si riferisce all India …   Enciclopedia Italiana

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