Small nucleolar RNA SNORD92

Small Nucleolar RNA SNORD92 (also known as HBII-316) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNOR92 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002 ] . This snoRNA is the human orthologue of mouse snoRNA MBII-316 cite journal |author= Huttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H,Bachellerie JP, Brosius J; |title= RNomics: an experimental approach that identifies 201 candidates fornovel, small, non-messenger RNAs in mouse. |journal= EMBO J |volume= 20 |issue= |pages= 2943–2953 |year= 2001 |pmid=11387227 |doi= 10.1093/emboj/20.11.2943] . SNORD92 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A3846 cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002] .

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=HBII-316 snoRNABase entry for SNORD92]