Hantzsch pyrrole synthesis

Hantzsch pyrrole synthesis

The Hantzch pyrrole synthesis is the chemical reaction of β-ketoesters (1) with ammonia (or primary amines) and α-haloketones (2) to give substituted pyrroles (3). [Hantzsch, A. "Ber." 1890, "23", 1474.] [Feist, F. "Ber." 1902, "35", 1538.]

References

ee also

*Knorr pyrrole synthesis
*Paal-Knorr synthesis


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