Small nucleolar RNA SNORA76

In molecular biology, SNORA76 (also known as ACA62) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. cite journal | last = Kiss | first = AM | coauthors = Jady BE, Bertrand E, Kiss T | year = 2004 | title = Human box H/ACA pseudouridylation guide RNA machinery | journal = Mol Cell Biol | volume = 24 | pages = 5797–5807 | pmid = 15199136 | doi = 10.1128/MCB.24.13.5797-5807.2004] .

This snoRNA was identified by computational screening and its expression in mouse experimentally verifiedby Northern blot and primer extension analysis cite journal |author= Schattner P, Barberan-Soler S, Lowe TM; |title= A computational screen for mammalian pseudouridylation guide H/ACARNAs. |journal= RNA |volume= 12 |issue= |pages= 15–25 |year= 2006 |pmid=16373490 |doi= 10.1261/rna.2210406] . ACA62 is proposed to guide the pseudouridylation of 18S rRNA U34and U105 ] cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002] .

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