HLA-A26

SerotypeA_normal
locus = A
type = 26
allelegroup = 26
broad = 10 | sister1 = 66 | sister2 = 43 | sister3 = 34 | sister4 = 25
oneallele = 01
dominant = 01
alleles = 4
common_alleles = 1
rare_alleles = 3
alias = A10
allele1 = 01
nick1 = A26.1
allele2 = 02
rallele1 = 02
rnick1 = A26.2
allele3 = 03
rallele2 = 03
rnick2 = A26.4
allele4 = 05
rallele3 = 05
rnick3 = -
mode = West Pacific Rim (Taiwan to Hokkaido)
lead_comment =
types =2
2ndType = 10
type1alle1freq = 97 |type2alle1freq = 2 |N1 = 1730
type1alle2freq = 81 | N2 = 31
type1alle3freq = 68 |type2alle3freq = 8 |N3 = 38
type1alle4freq = 90 | N4 = 10
serotype_comment = reasonably good serotyping with no overt false recognition.

Distribution

AlleleFreq
Placement = right
Allele = A*2601
Freq1 = 21.8 | People1 = Taiwan Taroko
Freq2 = 19.3 | People2 = Taiwan Bunun
Freq3 = 17.0 | People3 = Japan Ainu Hokkaido
Freq4 = 14.0 | People4 = Taiwan Rukai
Freq5 = 12.4 | People5 = USA Hawaii Okinawa
Freq6 = 11.7 | People6 = Georgia Tibilisi Kurds
Freq7 = 10.3 | People7 = Pakistan Baloch
Freq8 = 10.2 | People8 = Oman
Freq9 = 9.8 | People9 = Pakistan Burusho
Freq10 = 8.3 | People10 = Pakistan Karachi Parsi
Freq11 = 8.2 | People11 = China Beijing
Freq12 = 8.2 | People12 = Pakistan Sindhi
Freq13 = 8.1 | People13 = Japan Central
Freq14 = 8.0 | People14 = Pakistan Brahui
Freq15 = 8.0 | People15 = Taiwan Atayal
Freq16 = 7.6 | People16 = India New Delhi
Freq17 = 7.3 | People17 = Bulgaria
Freq18 = 7.3 | People18 = PNG New Britain Rabaul
Freq19 = 6.4 | People19 = Taiwan Hakka
Freq20 = 6.3 | People20 = Georgia Svaneti Svans
Freq21 = 6.1 | People21 = Pakistan Pathan
Freq22 = 6.0 | People22 = American Samoa
Freq23 = 6.0 | People23 = South Korea (3)
Freq24 = 5.5 | People24 = Israel Arab Druse
Freq25 = 5.3 | People25 = Croatia
Freq26 = 4.9 | People26 = Taiwan Saisiat
Freq27 = 4.9 | People27 = Taiwan Tsou
Freq28 = 4.8 | People28 = Cape Verde Northwestern I…
Freq29 = 4.7 | People29 = China Tibetan
Freq30 = 4.5 | People30 = China Qinghai Hui
Freq31 = 4.5 | People31 = Iran Baloch
Freq32 = 4.5 | People32 = Russia Tuva (2)
Freq33 = 4.3 | People33 = France South East
Freq34 = 4.3 | People34 = Portugal North
Freq35 = 4.3 | People35 = Senegal Niokholo Mandenka
Freq36 = 4.2 | People36 = USA Caucasian (2)
Freq37 = 4.0 | People37 = India Andhra Pradesh Goll…
Freq38 = 3.9 | People38 = Taiwan Paiwan
Freq39 = 3.9 | People39 = USA Hispanic
Freq40 = 3.8 | People40 = Romanian
Freq41 = 3.5 | People41 = Jordan Amman
Freq42 = 3.5 | People42 = Saudi Arabia Guraiat and …
Freq43 = 3.4 | People43 = China Inner Mongolia
Freq44 = 3.3 | People44 = Georgia Tibilisi Georgian…
Freq45 = 3.2 | People45 = USA Asian
Freq46 = 3.1 | People46 = Guinea Bissau
Freq47 = 3.0 | People47 = Ireland South
Freq48 = 3.0 | People48 = Singapore Javanese Indone…
Freq49 = 3.0 | People49 = Taiwan Puyuma
Freq50 = 2.8 | People50 = Czech Republic
Freq51 = 2.7 | People51 = Taiwan Pazeh
Freq52 = 2.5 | People52 = Brazil
Freq53 = 2.5 | People53 = PNG Madang
Freq54 = 2.4 | People54 = Mexico Guadalajara Mestiz…
Freq55 = 2.4 | People55 = Mexico Mestizos
Freq56 = 2.3 | People56 = Singapore Chinese Han
Freq57 = 2.2 | People57 = Australia New South Wales
Freq58 = 2.2 | People58 = China Yunnan Lisu
Freq59 = 2.1 | People59 = Burkina Faso Rimaibe
Freq60 = 2.0 | People60 = Cameroon Beti
Freq61 = 2.0 | People61 = China Guangzhou
Freq62 = 2.0 | People62 = Portugal South
Freq63 = 2.0 | People63 = Singapore Riau Malay
Freq64 = 2.0 | People64 = South Africa Natal Tamil
Freq65 = 2.0 | People65 = Taiwan Siraya
Freq66 = 2.0 | People66 = USA African Americans (2)
Freq67 = 1.9 | People67 = India North Hindus
Freq68 = 1.8 | People68 = Ireland Northern
Freq69 = 1.8 | People69 = Sudanese
Freq70 = 1.7 | People70 = Cameroon Yaounde
Freq71 = 1.7 | People71 = India North Delhi
Freq72 = 1.7 | People72 = Pakistan Kalash
Freq73 = 1.7 | People73 = Taiwan Thao
Freq74 = 1.6 | People74 = China South Han
Freq75 = 1.6 | People75 = USA North American Native…
Freq76 = 1.6 | People76 = Zimbabwe Harare Shona
Freq77 = 1.5 | People77 = Uganda Kampala
Freq78 = 1.4 | People78 = Mongolia Buriat
Freq79 = 1.4 | People79 = Thailand
Freq80 = 1.2 | People80 = New Caledonia
Freq81 = 1.2 | People81 = Zambia Lusaka
Freq82 = 1.1 | People82 = Finland
Freq83 = 1.0 | People83 = Ch. Guangdong Meizhou H…AlleleFreq
Placement = left
Allele = A*2602
Freq1 = 2.3 | People1 = Japan Central
Freq2 = 1.6 | People2 = USA North American Native…
Freq3 = 1.3 | People3 = Japan (5)
Freq4 = 1.1 | People4 = Japan Okinawa Ryukuan
Freq5 = 0.6 | People5 = Pakistan Brahui
Freq6 = 0.6 | People6 = South Korea (3)
Freq7 = 0.6 | People7 = USA San Antonio Caucasian…
Freq8 = 0.4 | People8 = Azores Terceira Island
Freq9 = 0.4 | People9 = USA Asian
Freq10 = 0.1 | People10 = Beijing Shijiazhuang Tian…AlleleFreq
Placement = right
Allele = A*2603
Freq1 = 8.6 | People1 = USA Hawaii Okinawa
Freq2 = 2.8 | People2 = Japan Okinawa Ryukuan
Freq3 = 2.4 | People3 = Japan Central
Freq4 = 2.0 | People4 = Japan Ainu Hokkaido
Freq5 = 1.3 | People5 = Japan (5)
Freq6 = 1.1 | People6 = India North Delhi
Freq7 = 1.0 | People7 = South Korea (3)
Freq8 = 0.5 | People8 = Spain Basque Gipuzkoa Pro…
Freq9 = 0.3 | People9 = China Tibetan
Freq10 = 0.3 | People10 = Romanian
Freq11 = 0.3 | People11 = USA African Americans pop…

Disease associations

A26 Serotype is associated with adult T-cell leukemia in Japanese. [cite journal | author = Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S | title = A family predisposition to adult T-cell leukemia. | journal = J Clin Exp Hematop | volume = 46 | issue = 2 | pages = 67–71 | year = 2006 | pmid = 17142956] [cite journal | author = Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S | title = HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes. | journal = AIDS Res Hum Retroviruses | volume = 17 | issue = 11 | pages = 1047–61 | year = 2001 | pmid = 11485622 | doi = 10.1089/088922201300343735]

References