Perkin reaction

Perkin reaction

The Perkin reaction is an organic reaction developed by William Henry Perkin that can be used to make cinnamic acids by the aldol condensation of aromatic aldehydes and acid anhydrides in the presence of an alkali salt of the acid. [Perkin, W. H.; "J. Chem. Soc." 1868, "21", 53, 181.] [Perkin, W. H.; "J. Chem. Soc." 1877, "31", 388.]

Several reviews have been written. [Johnson, J. R.; "Org. React." 1942, "1", 210. (Review)] [House, H. O. "Modern Synthetic Reactions" (W. A. Benjamin, Menlo Park, California, 2nd ed, 1972) pp 660-663.] [Rosen, T.; "Comp. Org. Syn." 1991, "2", 395-408. (Review)]

The above mechanism is not universally accepted, as several versions exist, including decarboxylation without acetic group transfer Fact|date=November 2007.

References

ee also

*Erlenmeyer-Plöchl azlactone and amino acid synthesis
*Stobbe condensation


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