HLA-A32

SerotypeA_normal
locus = A
type = 32
allelegroup = 32
oneallele = 01
alleles = 1
alias = "A19"
broad = 19 | sister1 = 74 | sister2 = 33 | sister3 = 31 | sister4 = 30 | sister5 = 29
nick1 = A19
common_alleles = 1
rare_alleles = 0
allele1 = 01
commonAllele = 01
dominant = 01
mode =
types = 1
type1alle1freq = 94 |N1 = 3441
serotype_comment = Serotyping efficiency for the predominant allele is good. There are 16 known allelesthat result in 15 isoforms of HLA-A32. One isoform may be poorly expressed.cite journal | author = Tang TF, Hou L, Tu B, "et al" | title = Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries | journal = Tissue Antigens | volume = 68 | issue = 6 | pages = 518–20 | year = 2006 | pmid = 17176443 | doi = 10.1111/j.1399-0039.2006.00707.x]

Distribution

AlleleFreq
Placement = right
Allele = A*3201
Freq1 = 11.4 | People1 = Oman
Freq2 = 9.2 | People2 = Pakistan Brahui
Freq3 = 8.7 | People3 = Italy Sardinia
Freq4 = 8.2 | People4 = Bulgaria
Freq5 = 8.2 | People5 = Burkina Faso Fulani
Freq6 = 7.8 | People6 = Pakistan Karachi Parsi
Freq7 = 7.5 | People7 = Pakistan Kalash
Freq8 = 7.2 | People8 = France South East
Freq9 = 7.1 | People9 = Pakistan Baloch
Freq10 = 7.0 | People10 = Greece North
Freq11 = 6.7 | People11 = Georgia Tibilisi Kurds
Freq12 = 6.7 | People12 = Iran Baloch
Freq13 = 6.0 | People13 = Spain North Cantabrian
Freq14 = 5.9 | People14 = Italy Bergamo
Freq15 = 5.8 | People15 = India North Hindus
Freq16 = 5.7 | People16 = Croatia
Freq17 = 5.5 | People17 = France Corsica
Freq18 = 5.5 | People18 = Scotland Orkney
Freq19 = 5.5 | People19 = Sudanese
Freq20 = 5.4 | People20 = Spain Eastern Andalusia
Freq21 = 5.1 | People21 = Algeria1
Freq22 = 5.1 | People22 = Azores Santa Maria and Sa…
Freq23 = 5.1 | People23 = Pakistan Pathan
Freq24 = 5.1 | People24 = Pakistan Sindhi
Freq25 = 5.0 | People25 = Romanian
Freq26 = 4.9 | People26 = Macedonia
Freq27 = 4.8 | People27 = Cape Verde Northwestern I…
Freq28 = 4.8 | People28 = Georgia Tibilisi Georgian…
Freq29 = 4.6 | People29 = Serbia
Freq30 = 4.4 | People30 = Ireland South
Freq31 = 4.4 | People31 = England Lancaster
Freq32 = 4.3 | People32 = Azores Terceira Island
Freq33 = 4.3 | People33 = USA Caucasian pop2
Freq34 = 4.2 | People34 = Bulgaria Gipsy
Freq35 = 4.0 | People35 = Cape Verde Southeastern I…
Freq36 = 4.0 | People36 = Israel Arab Druse
Freq37 = 4.0 | People37 = Portugal Centre
Freq38 = 3.8 | People38 = Burkina Faso Mossi
Freq39 = 3.8 | People39 = Guinea Bissau
Freq40 = 3.8 | People40 = Spain North Cabuernigo
Freq41 = 3.7 | People41 = Belguim
Freq42 = 3.7 | People42 = Russia Chuvash
Freq43 = 3.5 | People43 = Sweden Stockholm
Freq44 = 3.5 | People44 = Wales
Freq45 = 3.5 | People45 = England Sheffield
Freq46 = 3.4 | People46 = England Leeds
Freq47 = 3.4 | People47 = Australia New South Wales
Freq48 = 3.4 | People48 = Morocco Berber Nador Meta…
Freq49 = 3.2 | People49 = Ireland Northern
Freq50 = 3.1 | People50 = Jordan Amman
Freq51 = 3.0 | People51 = India Khandesh Pawra
Freq52 = 3.0 | People52 = India New Delhi
Freq53 = 3.0 | People53 = India West Coast Parsis
Freq54 = 3.0 | People54 = USA Hispanic
Freq55 = 2.8 | People55 = Turkey
Freq56 = 2.7 | People56 = Sweden Uppsala County
Freq57 = 2.7 | People57 = India North Delhi
Freq58 = 2.7 | People58 = Morocco
Freq59 = 2.7 | People59 = Pakistan Burusho
Freq60 = 2.6 | People60 = Kenya Luo
Freq61 = 2.5 | People61 = South Africian Natal Zulu
Freq62 = 2.4 | People62 = China North Han
Freq63 = 2.4 | People63 = Czech Republic
Freq64 = 2.4 | People64 = London Ashkenazi Jews
Freq65 = 2.4 | People65 = Mexico Mestizos
Freq66 = 2.4 | People66 = Saudi Arabia Guraiat and …
Freq67 = 2.2 | People67 = China Beijing
Freq68 = 2.2 | People68 = Finland
Freq69 = 2.2 | People69 = Uganda Kampala
Freq70 = 2.1 | People70 = Russia Tuva pop 2
Freq71 = 2.1 | People71 = USA North American Native…
Freq72 = 2.0 | People72 = Brazil
Freq73 = 2.0 | People73 = Cameroon Beti
Freq74 = 2.0 | People74 = Peru Arequipa
Freq75 = 2.0 | People75 = Russia Arkhangelsk Pomors
Freq76 = 1.9 | People76 = Italy North pop 1
Freq77 = 1.8 | People77 = Russia Northwest
Freq78 = 1.8 | People78 = German Essen
Freq79 = 1.6 | People79 = Spain Pas Valley
Freq80 = 1.6 | People80 = USA African America
Freq81 = 1.5 | People81 = Tunisia
Freq82 = 1.3 | People82 = Georgia Svaneti Svans
Freq83 = 1.2 | People83 = New Caledonia
Freq84 = 1.2 | People84 = South Africa Tswana

A32 is most common around the Persian Gulf and the Mediterranean Basin. It has a consistent presence in Europe. The A32 frequenceies in the more isolated (genetically) peoples of Europe suggests that the A32 rise in the Mediterranean may only be partially attributable to recent migrations from the middle eastern region. There is a node in southern Europe around the Ionian Sea in which specific, European, A32-haplotypes are elevated.

Haplotypes

A common A32 haplotype A*3201-B*5101 can be found in Oman, United Arab Emirates, SE Iran, Bulgaria, and Portugal. A second, A*3201-B*3501 can be in the Omani, UAE, and Portugal.

References