Formins

Formins (formin homology proteins) are a group of proteins that are involved in the polymerisation of actin and associate with the fast-growing end (barbed end) of actin filaments [cite journal | author= Evangelista Marie, Zigmond Sally and Boone Charles | title=Formins: signaling effectors for assembly and polarization of actin filaments | journal= J Cell Sci. | year=2003 |month=July| pages=2603–11 | volume=116 | issue=Pt 13 | pmid=12775772 | doi=10.1242/jcs.00611] . The structure of formins is mainly conserved in the C-terminal Formin Homology (FH) domains namely FH1, FH2 and the more loosely defined FH3 domain [cite journal | author= Wallar Bradley J and Alberts Arthur S | title=The formins: active scaffolds that remodel the cytoskeleton | journal= Trends Cell Biol. | year=2003 |month=August| pages=435–46 | volume=13 | issue=8 | pmid=12888296 | doi=10.1016/S0962-8924(03)00153-3] . The actin nucleation-promoting activity of "S. cerevisiae" formins has been localized to the FH1-FH2 domains. Other commonly shared domains are a GTPase binding domain (GBD) that bind for example Cdc42 at the N-terminus, and a DAD or Dia-autoregulatory domain, toward the C-terminus.

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