- Pumiliotoxin
Pumiliotoxins (PTXs), are one of several toxins found in the skin of
poison dart frog s. Closely related, though more toxic, areallopumiliotoxin s, (aPTXs). Other toxins found in the skin of poison frogs includedecahydroquinolines (DHQs),izidines ,coccinellines , andspiropyrrolizidines . Pumiliotoxins are very poisonous in high concentration. Pumiliotoxins are much weaker than that of thebatrachotoxin s, they can be between 100-1000 times weaker. There are three different types of this toxin A, B and C. Toxins A and B are a lot more toxic than C. Pumiliotoxins affect the body because they interfere with muscle contraction in the heart and skeletal muscle. The toxin works by affecting the calcium channels. Some of the symptoms of pumiliotoxins are partial paralysis, having difficulty moving, being hyperactive and in some cases it can result in death.References
* [http://jrscience.wcp.muohio.edu/fieldcourses06/PapersCostaRicaArticles/PoisonDartFrogs.html Poison Dart Frogs]
* [http://www.bio.davidson.edu/Courses/anphys/2000/Todd/toxintype.htm Toxins in Poison Dart Frogs]
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