Bcr-abl fusion protein is an
It is associated with
BCR ABL Fusion Protein comes in three flavors P190, P210 and P230 depending on the breakpoint on the BCR Fragment.
The P190 isoform can be produced by
External links
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Fusion protein — This article is about chimeric fusion proteins. For proteins involved in membrane fusion, see membrane fusion protein. Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes which originally coded for… … Wikipedia
Bcr-Abl tyrosine-kinase inhibitor — Bcr Abl tyrosine kinase inhibitors (TKI) are the first line therapy for most patients with chronic myelogenous leukemia (CML). In more than 90% cases CML is caused by chromosomal abnormality resulting in the formation of a so called Philadelphia… … Wikipedia
Bcr-Abl — Белок Bcr Abl гибридный белок (англ. Fusion protein), ассоциированный с филадельфийской хромосомой, приводит к активации путей внутриклеточной передачи сигнала, что делает клетку нечувствительной к воздействию факторов роста и вызывает … Википедия
BCR gene — The BCR gene is one of the two genes in the bcr abl complex, which is associated with the Philadelphia chromosome.PathologyA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in… … Wikipedia
Abl gene — The abl gene is associated with chronic myelogenous leukemia (CML). The abl gene is located on the 9th chromosome. In CML, the gene is activated by being translocated within the bcr (breakpoint cluster region) gene on chromosome 22. This new… … Wikipedia
Fusion gene — A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. The fusion of two genes is often taken as evidence that these genes have… … Wikipedia
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Drug design — Not to be confused with Designer drug. Drug design, also sometimes referred to as rational drug design or structure based drug design, is the inventive process of finding new medications based on the knowledge of the biological target.[1] The… … Wikipedia
genetic disease, human — Introduction any of the diseases and disorders that are caused by mutations in one or more genes (gene). With the increasing ability to control infectious and nutritional diseases in developed countries, there has come the realization … Universalium
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