Kuru (disease)

Kuru (disease)

Infobox_Disease
Name = Kuru


Caption =
DiseasesDB = 31861
ICD10 = ICD10|A|81|8|a|80
ICD9 = ICD9|046.0
ICDO =
OMIM =
MedlinePlus = 001379
eMedicineSubj = med
eMedicineTopic = 1248
MeshID = D007729

Kuru is a disease which affects the brain. It was endemic among the Fore tribe of Papua New Guinea and was universally fatal. It is characterized by headaches, joint pains and shaking of the limbs. It is believed to be caused by prions and is related to Creutzfeldt-Jakob disease.cite journal | author= Collinge J, Whitfield J, McKintosh E, et al | title =Kuru in the 21st century—an acquired human prion disease with very long incubation periods | journal =Lancet | volume =367 | issue =9528 | pages =2068–74 | publisher = | date =Jun 2006 | pmid=16798390 | doi =10.1016/S0140-6736(06)68930-7 ] It is best known for the epidemic that occurred in Papua New Guinea in the middle of the twentieth century. [ [http://www.ninds.nih.gov/disorders/kuru/kuru.htm Kuru Information Page: National Institute of Neurological Disorders and Stroke (NINDS) ] ] The word "kuru" means "trembling with fear" in the language of the Fore people, those most commonly afflicted with the disease. [http://www.emedicine.com/med/topic1248.htm eMedicine - Kuru : Article by Paul A Janson ] ] It is also known as the "laughing sickness" due to the pathologic bursts of laughter the patient displays when afflicted with the disease. [Purdey, Mark. " [http://www.ourcivilisation.com/madcow/kuru.htm Explanation of Kuru Disease] "] Trembling is present in almost all patients with transmissible spongiform encephalopathy.

History

Kuru was first noted in native people of New Guinea in 1957–1959. It was in the late 1950s that the full extent of the disease was realized, after it had reached large infection rates in the South Fore of the Okapa Subdistrict, though the agent was unknown. [ [http://www.as.ua.edu/ant/bindon/ant570/Papers/McGrath/McGrath.htm Kuru: The Dynamics of a Prion Disease ] ]

The disease was researched by Daniel Carleton Gajdusek who was awarded (with Baruch S. Blumberg) the Nobel Prize in Physiology or Medicine in 1976 for his work on it.

Transmission

It is believed by some that the disease spread easily in the Fore people due to their cannibalistic funeral practices. The dysmorphism evident in the infection rates—it was more prevalent in women and children—is because while the men of the village ate the flesh of the deceased, the women and children ate the brain, where the disease particles are concentrated. There is also the strong possibility that it was passed on to women and children more easily because they took on the task of cleaning relatives after death. [http://www.emedicine.com/med/topic1248.htm eMedicine - Kuru : Article by Paul A Janson ] ] With elimination of these practices, Kuru disappeared among the South Fore within a generation.

References


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