Amsterdam criteria

Amsterdam criteria

The Amsterdam criteria identify families likely to have Hereditary nonpolyposis colorectal cancer (HNPCC).

At least 3 relatives with an HNPCC-associated cancer: colorectal cancer, or cancer of the endometrium, small intestine, ureter or renal pelvis.

* One patient should be a first degree relative of the other two

* At least two successive generations should be affected

* At least one tumour should be diagnosed <50 years of age

* Familial adenomatous polyposis should be excluded in the colorectal cancer case (if any)

* Tumours should be verified by histopathologic examination

References

*cite web |url=http://www.jeffersonhospital.org/cancer/article3099.html |title=Recognizing Hereditary Cancer |format= |work=homas Jefferson University Hospital |accessdate=

*cite web |author=Half EE, Bresalier RS |year=2004 |url=http://www.medscape.com/viewarticle/466572_4 |title=Clinical Management of Hereditary Colorectal Cancer Syndromes |format= |work=Medscape & eMedicine |accessdate=
*cite journal |author=Vasen HF, Watson P, Mecklin JP, Lynch HT |title=New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC |journal=Gastroenterology |volume=116 |issue=6 |pages=1453–6 |year=1999 |pmid=10348829 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0016508599005715


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