Xist

Xist

Xist is an RNA gene on the X chromosome of the placental mammals that acts as major effector of the X inactivation process.

The Xist RNA, a large (17 kb in humans) [cite journal |author=Brown CJ, Hendrich BD, Rupert JL, "et al" |title=The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus |journal=Cell |volume=71 |issue=3 |pages=527–42 |year=1992 |pmid=1423611 |doi=] transcript, is expressed on the inactive chromosome and not on the active one. It is processed similarly to mRNAs, through splicing and polyadenylation, however, it remains untranslated. It has been suggested that this RNA gene evolved at least partly from a protein coding gene that became a pseudogene.cite journal | author = Duret L, Chureau C, Samain S, Weissenbach J, Avner P | title = The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene | journal = Science | volume = 312 | issue = 5780 | pages = 1653–5 | year = 2006 | pmid = 16778056 | doi = 10.1126/science.1126316 | issn = ]

The inactive X is coated with this transcript, which is essential for the inactivation. X lacking Xist will not be inactivated, while duplication of the Xist gene on another chromosome causes inactivation of that chromosome.

References

External links

* [http://spot.colorado.edu/~strauswm/tech/xist_function.html Xist page of Strauss lab]


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  • XIST — XIST. См. Xi specific transcript. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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  • XIST (gene) — X (inactive) specific transcript, also known as XIST, is a human gene.cite web | title = Entrez Gene: XIST X (inactive) specific transcript| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7503| accessdate …   Wikipedia

  • XIST — Candidate Gene for X inactivation Center (Medical » Human Genome) …   Abbreviations dictionary

  • XIST — inactive X chromosome specific transcript; X inactivation specific transcript * * * [X inactivation–specific transcript] see under gene …   Medical dictionary

  • XIST — abbr. Candidate Gene for X Inactivation Center …   Dictionary of abbreviations

  • xıştək — I (Lənkəran) bax xişdəx’ I. – Köynəyin xişdəyi yırtılıb II (Mingəçevir) bax xişdəx’ II …   Azərbaycan dilinin dialektoloji lüğəti

  • XIST — • inactive X chromosome specific transcript; • X inactivation specific transcript …   Dictionary of medical acronyms & abbreviations

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