Vaccine interference

Vaccine interference is a phenomenon which occurs when two or more vaccines are mixed together in the same formulation. This most frequently occurs with live attenuated vaccines, where one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 2 viruses in the vaccine. [cite book|author=Sutter RW, Cochi SL, Melnick JL|year=1999|chapter=Live attenuated polio vaccines|editor=Plotkin SA, Orenstein WA (eds.)|title=Vaccines|location=Philadelphia|publisher=W. B. Saunders|pages=364–408] This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, -2 and -4 serotypes. [cite journal|author=Kanesa-thasan N, Sun W, Kim-Ahn G, "et al."|year=2001|title=Safety and immunogenicity of attenuated dengue virus vaccines (Aventis Pasteur) in human volunteers|journal=Vaccine|volume=19|issue=23–24|pages=3179–3188|pmid=11312014|doi=10.1016/S0264-410X(01)00020-2]

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