- Lapachol
Chembox new
Reference= [http://www.rdchemicals.com/chemicals.php?mode=details&mol_id=7988] Lapochol at R&D Chemicals.] [http://www.chromadex.com/chemicals/CDXProductPageH8r2mS8767c.html] Lapochol at CromaDex.]
ImageFile=Lapachol.png
IUPACName=4-Hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
OtherNames=
Section1= Chembox Identifiers
CASNo=84-79-7
PubChem=3884
SMILES=CC(=CCC1=C(C2=CC=CC=C2C(=O)C1=O)O)C
Section2= Chembox Properties
Formula=C15H14O3
MolarMass=242.27
Appearance=Yellow crystals
Density=
MeltingPtC=140
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=Lapachol is a natural
organic compound isolated from the lapacho tree ("Tabebuia avellandedae") [Record, Samuel J. Lapachol. Tropical Woods (1925), 1 7-9.] Chemically, it is a derivative ofnaphthoquinone , related tovitamin K .Once studied as a possible treatment for some types of cancer, lapachol's potential is now considered low due to its toxic side effects. [cite journal |author=Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O |title=Fetal growth in rats treated with lapachol |journal=Contraception |volume=66 |issue=4 |pages=289–93 |year=2002 |pmid=12413627 |doi=] [Oral toxicology studies with lapachol. Morrison, Robert K.; Brown, Donald Emerson; Oleson, Jerome J.; Cooney, David A. Toxicology and Applied Pharmacology (1970), 17(1), 1-11.] [cite journal |author=Guerra Mde O, Mazoni AS, Brandão MA, Peters VM |title=Toxicology of Lapachol in rats: embryolethality |journal=Brazilian journal of biology = Revista brasleira de biologia |volume=61 |issue=1 |pages=171–4 |year=2001 |pmid=11340475 |doi=] [cite journal |author=de Cássia da Silveira E Sá R, de Oliveira Guerra M |title=Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment |journal=Phytotherapy research : PTR |volume=21 |issue=7 |pages=658–62 |year=2007 |pmid=17421057 |doi=10.1002/ptr.2141]
References
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