Small Modular ImmunoPharmaceuticals

Small Modular ImmunoPharmaceuticals

Small Modular ImmunoPharmaceuticals, also knows as SMIPs, is novel class of drugs, a single-chain polypeptides, therapeutic antibodies [http://www.bumc.bu.edu/www/busm/itp/PDFs/Hohlbaum1.pdf] . Being one third to half the size of corresponding monoclonal antibodies, they have similar in vivo half life and better tissue penetration properties [http://www.trubion.com/pdf/Trubion_SMIP_Drug_Design.pdf] .

References

SMIP, or small modular immunopharmaceutical, therapeutics are single chain polypeptides comprising one binding domain, one hinge domain and one effector domain designed in an effort to meet predetermined therapeutic specifications for specific diseases. SMIP therapeutics are mono-specific (they recognize and attach to single antigen targets and initiate biological activity). Trubion is working on SMIP drug candidates that target validated antigens with the same specificity and predictable biological activity as mAbs.


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  • Trubion — Trubion is a publicly held biopharmaceutical company that is focused on creating a pipeline of protein based therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer. Trubion was established in 1999 in the State of …   Wikipedia

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