G12/G13 alpha subunits

protein
Name= guanine nucleotide binding protein (G protein) alpha 12
caption=


width=
HGNCid=4380
Symbol=GNA12
AltSymbols=
EntrezGene=2768
OMIM=604394
RefSeq=NM_007353
UniProt=Q03113
PDB=
ECnumber=
Chromosome=7
Arm=p
Band=22.3
LocusSupplementaryData=protein
Name=guanine nucleotide binding protein (G protein), alpha 13
caption=


width=
HGNCid=4381
Symbol=GNA13
AltSymbols=
EntrezGene=10672
OMIM=604406
RefSeq=NM_006572
UniProt=Q14344
PDB=
ECnumber=
Chromosome=17
Arm=q
Band=24
LocusSupplementaryData=

G12/G13 subunits are alpha units of heterotrimeric G proteins which regulate cell process through the use of guanine nucleotide exchange factors.cite journal | author = Dhanasekaran N, Dermott JM | title = Signaling by the G12 class of G proteins | journal = Cell. Signal. | volume = 8 | issue = 4 | pages = 235–45 | year = 1996 | pmid = 8842523 | doi = 10.1016/0898-6568(96)00048-4 | issn = ] These two subunits represent a fourth class of G protein alpha subunits.cite journal | author = Strathmann MP, Simon MI | title = G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 13 | pages = 5582–6 | year = 1991 | pmid = 1905812 | doi = 10.1073/pnas.88.13.5582 | issn = ] They are not sensitive to pertussis toxin.cite journal | author = Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G | title = Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain | journal = Biochem. J. | volume = 319 ( Pt 1) | issue = | pages = 165–71 | year = 1996 | pmid = 8870664 | doi = | issn = | url = http://www.biochemj.org/bj/319/bj3190165.htm ]

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.cite journal | author = Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY | title = G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles | journal = J. Biol. Chem. | volume = 281 | issue = 43 | pages = 32660–7 | year = 2006 | pmid = 16943201 | doi = 10.1074/jbc.M604588200 | issn = ] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.cite journal | author = Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY | title = The G protein G alpha(13) is required for growth factor-induced cell migration | journal = Dev. Cell | volume = 10 | issue = 6 | pages = 707–18 | year = 2006 | pmid = 16740474 | doi = 10.1016/j.devcel.2006.03.014 | issn = ]

Genes

* GNA12 (gene|GNA12), gene|GNA13

References

External links

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