Scavenger receptor class B1

Scavenger receptor class B1

Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. It is best known for its role in facilitating the uptake of cholesteryl esters from high density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver for excretion. This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.SR-BI has also been identified in the livers of non-mammalian species (turtle, goldfish, shark, chicken, frog and skate), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SB-RI during egg development, indicating cholesterol efflux may be at peak levels during this time of year in turtles [ [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11857477 Expression of SR-BI (Scavenger Receptor Class B Ty... [J Exp Zool. 2002 - PubMed Result ] ] .

References

Duggan, A.E., et al. 2002. J Exp Zoo 292:439-434 PMID:11857477 [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11857477]


Wikimedia Foundation. 2010.

Поможем написать курсовую<

Look at other dictionaries:

  • Scavenger receptor — Scavenger receptors are a group of receptors that recognize modified low density lipoprotein (LDL) by oxidation or acetylation. This naming is based on a function of cleaning (scavenging): scavenger receptors widely recognize and uptake… …   Wikipedia

  • scavenger receptor — Structurally diverse family of receptors on macrophages that are involved in the uptake of modified LDL and have been implicated in development of atherosclerotic lesions. Six classes are recognized with different binding preferences. Macrophage… …   Dictionary of molecular biology

  • Receptor — In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are hoards of receptors. There are receptors for insulin, receptors for low density lipoproteins (LDL), etc.… …   Medical dictionary

  • Pattern recognition receptor — Pattern recognition receptors (PRRs) are a primitive part of the immune system. They are proteins expressed by cells of the innate immune system to identify pathogen associated molecular patterns (PAMPs), which are associated with microbial… …   Wikipedia

  • NOD-like receptor — The NOD like receptors (NLRs), in short for Nucleotide Oligomerization Domain receptors, are cytoplasmic proteins that may have a variety of functions in regulation of inflammatory and apoptotic responses. NLRs are encoded by genes from a large… …   Wikipedia

  • RAGE (receptor) — RAGE, the receptor for advanced glycation endproducts is a 35kD transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. [cite journal author = Neeper, M; Schmidt, AM; Brett, J; Yan, SD;… …   Wikipedia

  • SCARB1 — Scavenger receptor class B, member 1, also known as SCARB1 (sometimes abbraviated to SRB1), is a human gene. [cite web | title = Entrez Gene: SCARB1 Scavenger receptor class B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • SCARB2 — Scavenger receptor class B, member 2, also known as SCARB2, is a human gene.cite web | title = Entrez Gene: SCARB2 scavenger receptor class B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=950|… …   Wikipedia

  • CD36 — (Cluster of Differentiation 36) is an integral membrane protein found on the surface of many cell types in vertebrate animals and is also known as FAT, SCARB3, GP88, glycoprotein IV (gpIV) and glycoprotein IIIb (gpIIIb). CD36 is a member of the… …   Wikipedia

  • HDL-Rezeptor — Masse/Länge Primärstruktur 552 Aminosäuren …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”