Loewe additivity

Loewe additivity is one several common reference models used for measuring the effects of drug combinations.

Loewe additivity is based on the idea that an agent should not have synergistic interactions with itself.

References

* William R Greco, Gregory Bravo, and John Parsons "The Search for Synergy: A Critical Review from a Response Surface Perspective", "Pharmacological Reviews" 47(2) 331-385 (1995)
* Loewe and Muischnek. "Effect of combinations: mathematical basis of the problem" "Arch. Exp. Pathol. Pharmakol." 114: 313-326, 1926