Ulrich Hagen

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name = Ulrich Hagen


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caption = Ulrich Hagen
birth_date = birth date|1925|2|21
birth_place = Frankfurt am Main , Germany

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nationality = German
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Ulrich Hagen (February 21, 1925 – November 25, 2007), a German scientist, is one of the German pioneers in the field of molecular radiation biology.

Hagen developed analytical techniques that would allow an examination and analysis of various types of DNA damage. He was among the first German radiation biologists to become aware of the important role of DNA repair in endpoints such as mutagenesis, aberration formation, cell death, and carcinogenesis.

Life

Hagen was born in Frankfurt am Main and raised in Augsburg, Germany where he attended the Anna Gymnasium. His father Wilhem Hagen was a pediatrician and later an important public health official in Germany. Ulrich Hagen graduated from the Ludwig Maximilians University of Munich with doctorial degrees in Medicine and Biology. In 1953, he was given a fellowship position at Heiligenberg Institute (one of the leading German institutes for Radiation Biology after WWII), which was then under the directorship of Hanns Langendorff.

In the early days at Heiligenberg, Professor Hagen researched the radioprotective substances and cell death in lymphocytes and conducted research in Stockholm, in Professor Forssberg’s laboratory. It was in Stockholm that Professor Hagen became acquainted with isolated DNA. There he realized the importance of the celluar effects of ionising radiation in relationship with DNA damage repair. Directely following, he began developing analytical techniques that would allow an examination and analysis of various types of DNA damage, which made Hagen an important pioneer in the field of Molecular Radiation Biology.

Ulrich Hagen continued his research work as ‘Privatdozent’ at the Radiological Institute of the University of Freiburg, from 1961 to 1965. In 1965, he accepted an appointment at the Institute of Radiation Biology of the Kernforschungszentrum Karlsruhe (under the leadership of Karl Günter Zimmer). He remained there for 12 years studying the structure of irradiated DNA. During those years, he recognized and documented the problem of RNA polymerase inhibition by damaged DNA templates and was among the first German radiation biologists to become aware of the important role of DNA repair, as relates to endpoints: mutagenesis, aberration formation, cell death, and carcinogenesis. Ulrich Hagen became the Director of the Institute of Radiation Biology of the GSF – Gesellschaft für Strahlenforschung in Neuherberg (which was later re-named GSF – National Research Center for Environment and Health), in 1979. As the Director of Radiation Biology of the GSF, he was able to unify a number of heterogeneous radiological disciplines that had arisen at the GSF institute. In 1995, he was elected President of the 10th International Congress of Radiation Research in Würzburg, Germany and was, for 16 years, the Managing Editor of Radiation and Environmental Biophysics, Springer-Verlag.

Awards and honors

Hagen's scientific career is documented by numerous publications and by several eminent awards:
*Röntgen Award, University of Giessen (1966)
*Weiss Medal, British Association for Radiation Research (1976) [ Announcement (July 1976), "International Journal of Radiation Biology",30(1):100. [http://dx.doi.org/10.1080/09553007614550861 DOI: 10.1080/09553007614550861] ] [ [http://www.graylab.ac.uk/usr/arr/weiss.html Association for Radiation Research website] . Accessed June 27, 2007.]
*Hanns-Lagendorff Medal (1997)

References

T. Roedler-Vogelsang and A. A. Friedl (2000). "Tribute to Professor Ulrich Hagen on the occasion of his 75th birthday." "Radiation and Environmental Biophysics", 39(1):1.

DNA Repair 2006: 9th Biennial Meeting of the German Society for Research on DNA Repair [http://www.dna-rep-net.de/hamburg_report.pdf]

Genomic integrity of T1 DNA after γ- and ultraviolet irradiation [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47TG4JS-XG&_user=10&_coverDate=02%2F27%2F1979&_alid=693531409&_rdoc=3&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e8200dd4ad87d795ef9c4f23655a262f]

Action of intercalating agents on the activity of DNA polymerase I [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47TG2RS-DK&_user=10&_coverDate=12%2F02%2F1977&_alid=693531409&_rdoc=4&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e2c374e32794bccb7927ec0335d8bf36]

In vitro repair of radiation-induced strand breaks in DNA [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47T1RTK-NF&_user=10&_coverDate=05%2F03%2F1976&_alid=693531409&_rdoc=5&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0bdfb1dfc68ad54f9fecfffc74dbaf1f]

Correlation between sedimentation coefficient and molecular weight of denatured DNA [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47T1PTX-7V&_user=10&_coverDate=12%2F20%2F1974&_alid=693531409&_rdoc=6&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c8b726bde61288b8d3cdc1d463279a3d]

Action of DNA polymerase I on γ-irradiated DNA [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47T8WGF-6M&_user=10&_coverDate=12%2F21%2F1973&_alid=693531409&_rdoc=7&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b6b242c3dbac82a66bf7b836d75ecf1f]

End group determination in γ-irradiated DNA [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-48657YD-11&_user=10&_coverDate=06%2F17%2F1970&_alid=693531409&_rdoc=9&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6228aeb1e750dcc667d9813e523d3374]

Bestimmung von Einzel- und Doppelbrüchen in bestrahlter desoxyribonukleinsäure durch die Molekulargewichtsverteilung [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47TG1X1-6C&_user=10&_coverDate=01%2F25%2F1967&_alid=693531409&_rdoc=12&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=8a12668907cd2a0327ee67e9f826554e]

Ultraviolet light inactivation of the priming ability of DNA in the RNA polymerase system [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G8-47V9BFX-J&_user=10&_coverDate=03%2F15%2F1965&_alid=693531409&_rdoc=13&_fmt=summary&_orig=search&_cdi=11520&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b3a0abc0a066e525f0bbae390ccd9954]

The effect of X-irradiation on the priming ability of DNA in the RNA polymerase system [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G7-47FWYMF-36&_user=10&_coverDate=05%2F18%2F1964&_alid=693531409&_rdoc=15&_fmt=summary&_orig=search&_cdi=11519&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e448e02f7f92476eb2e2d77f4dfa91bb]

Radiosensitivity of glycolytic enzymes in the nucleus [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B73G9-4894KS1-KK&_user=10&_coverDate=12%2F31%2F1963&_alid=693531409&_rdoc=16&_fmt=summary&_orig=search&_cdi=11521&_sort=d&_docanchor=&view=c&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9806c26b220060a6e91f203b836ce722]

External links

GSF - Forschungszentrum für Umwelt und Gesundheit [http://www.gsf.de/]

Springer Berlin / Heidelberg [http://www.springerlink.com/content/p242600qng2431h6/]