90Y-DOTA-biotin

⁹⁰Y-DOTA-biotin consists of a radioactive substance (yttrium-90) complexed by a chelating agent (DOTA), which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been conducted^[1][2] as well as clinical studies in humans.^[3][4]

In pretargeted radioimmunotherapy, two or three medications are applied in succession. At first, an antibody-drug conjugate is administered, which consists of a monoclonal antibody designed to target the tumour, and a chemical marker which in the case of DOTA-biotin therapy is one of the proteins avidin and streptavidin. After a time of typically one or two days to let the antibody accumulate in the tumour, a clearing agent may be given to eliminate residues of antibody that are still circulating in the bloodstream; this is especially done in humans. After a further waiting time, the radiotherapy (⁹⁰Y-DOTA-biotin) is administered. Due to the high affinity of biotin to avidin and streptavidin, the radiotherapy accumulates where the antibody is, namely in the tumour, where it delivers its radioactivity.^[3]

Example of a ⁹⁰Y-DOTA-biotin compound. The structure of the linker, as well as its binding position to DOTA, may vary.^[5]

References

1. ^ Domingo RJ, Reilly RM (2000). "Pre-targeted radioimmunotherapy of human colon cancer xenografts in athymic mice using streptavidin-CC49 monoclonal antibody and 90Y-DOTA-biotin". Nuclear medicine communications 21 (1): 89–96. doi:10.1097/00006231-200001000-00015. PMID 10717908. 
2. ^ Pagel JM, Kenoyer AL, Bäck T, et al. (May 2011). "Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model". Blood 118 (3): 703–11. doi:10.1182/blood-2011-04-347039. PMC 3142907. PMID 21613259. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=21613259. 
3. ^ ^{a b} Knox, SJ; Goris, ML; Tempero, M; Weiden, PL; Gentner, L; Breitz, H; Adams, GP; Axworthy, D et al. (2000). "Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer". Clinical cancer research : an official journal of the American Association for Cancer Research 6 (2): 406–14. PMID 10690517. 
4. ^ Paganelli, G.; Ferrari, M.; Ravasi, L.; Cremonesi, M.; De Cicco, C.; Galimberti, V.; Sivolapenko, G.; Luini, A. et al. (2007). "Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer". Clinical Cancer Research 13 (18): 5646s–5651s. doi:10.1158/1078-0432.CCR-07-1058. PMID 17875802. 
5. ^ Schultz, Michael K.; Parameswarappa, Sharavathi G.; Pigge, F. Christopher (2010). "Synthesis of a DOTA−Biotin Conjugate for Radionuclide Chelation via Cu-Free Click Chemistry". Organic Letters 12 (10): 2398–401. doi:10.1021/ol100774p. PMID 20423109. 

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Biomolecules Radiopharmaceuticals Antineoplastic and immunomodulating drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат John Hubley Burgazada Look at other dictionaries: 90Y-DOTA-biotin — A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. 90Y DOTA biotin will find tumor cells in the body that have been targeted by an antibody… …   English dictionary of cancer terms 90Y-DOTA-biotin — noun The vitamin biotin labelled with radioactive (yttrium 90); it is used in the treatment of cancer where it seeks out tumor cells that have been targeted by an antibody linked to strepavidin and kill them …   Wiktionary yttrium Y 90 DOTA-biotin — A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA biotin will find tumor cells in the body that have been targeted by an… …   English dictionary of cancer terms DOTA (chelator) — DOTA IUPAC name 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid …   Wikipedia List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”