- Evolution of Vitamin C
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cleanup = June 2007
OR = March 2008
expert = Molecular and Cellular BiologySome 400-300 million years ago (Mya) when living
plants andanimals first began the move from the sea to rivers and land, environmentaliodine deficiency was a challenge to theevolution of terrestrial life (Venturi et al., 1999; 2000). In plants, animals (and fishes) the terrestrial diet became deficient in many essential marinemicronutrients , includingiodine ,selenium ,zinc ,copper ,manganese ,iron , etc.Freshwateralgae and terrestrial plants, in replacement of marineantioxidant s, slowly optimized the production of otherendogenous antioxidants such asascorbic acid , polyfenols,carotenoid s,flavonoid s, tocoferols etc., some of which became essential “vitamin s” in the diet of terrestrial animals (vitamins C, A, E, etc.).Ascorbic acid or Vitamin C is a common enzymaticcofactor in mammals used in the synthesis ofcollagen . Ascorbate is a powerfulreducing agent capable of rapidly scavenging a number ofreactive oxygen species (ROS). Freshwaterteleost fishes also require dietary vitamin C in their diet or they will get scurvy (Hardie et al.,1991). The most widely recognized symptoms of vitamin C deficiency in fishes arescoliosis ,lordosis and dark skin coloration. Terrestrial freshwaterssalmonid s also show impairedcollagen formation, internal/fin haemorrhage, spinal curvature and increased mortality.If these fishes are housed in seawater with algae and phytoplankton, then vitamin supplementation seems to be less important, presumably because of the availability of other, more ancient, antioxidants in natural marine environment (Hardie et al.,1991).Venturi and Venturi (2004, 2007) suggested that the antioxidant action of ascorbic acid developed firstly in plant kingdom when, about 500 Mya, plants began to adapting themselves to mineral deficient fresh-waters of estuary of rivers. Some biologists suggested that many vertebrates had developed their metabolic adaptive strategies in estuary environment (Purves et al., 1998). Like plants, most mammals (with the exception of humans and
guinea pig s) make their ascorbic acid fromglucose and can make glucose from ascorbic acid. Someprimates , remote ancestors of humans, underwent a geneticmutation about 40-45 million years ago and haven't been able to make “vitamin C” since. Therefore living humans need nowadays to get all “vitamin C” from food. Some scientists think that the loss of human ability to make “vitamin C” may have caused Homo sapiens' rapid evolution into modern man (Challem et al., 1998; Benhegyi et al., 1997; Stone, 1979).References
1. Benhegyi, G. 1997. Ascorbate metabolism and its regulation in animals. Free Radical Biology and Medicine. 23(5):793-803.
2. Challem, JJ, Taylor, EW. 1998. Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens. Free Radical Biology and Medicine. 25(1):130-132.
3. Hardie LJ, Fletcher TC, Secombes C.J.1991. The effect of dietary vitamin C on the immune response of the Atlantic salmon (Salmo salar). Aquaculture 95:201–214
4. Purves WK, Sadava D, Orians GH, Heller HC. 1998. Life.The Science of Biology. Part 4: The Evolution of Diversity. Chapter 30
5. Stone I. 1979. Homo sapiens ascorbicus, a biochemically corrected robust human mutant. Medical Hypotheses. 5(6):711-721
6. Venturi S, Venturi M. 1999. Iodide, thyroid and stomach carcinogenesis: Evolutionary story of a primitive antioxidant? Eur J Endocrinol . 140:371-372.
7. Venturi S, Donati FM, Venturi A, Venturi M. 2000. Environmental iodine deficiency: A challenge to the evolution of terrestrial life? Thyroid. 10 (8):727-9.
8. Venturi S. and Venturi M. 2004. Iodine and Evolution. Dimi Marche News. Dipartimento Interaziendale di Medicina Interna della Regione Marche. Published on-line, February 8, 2004. http://web.tiscali.it/iodio/
9. Venturi S, Venturi M. Evolution of Dietary Antioxidant Defences. European EPI-Marker. 2007, 11, 3 :1-12
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