- Randle cycle
The Randle cycle is a metabolic process involving the competition of
glucose andfatty acid s for substrates. [cite journal |author=Bevilacqua S, Buzzigoli G, Bonadonna R, "et al" |title=Operation of Randle's cycle in patients with NIDDM |journal=Diabetes |volume=39 |issue=3 |pages=383–9 |year=1990 |pmid=2307295 |doi=] It is theorized to play a role in explainingtype 2 diabetes andinsulin resistance . [cite journal |author=Shuldiner AR, McLenithan JC |title=Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again |journal=J. Clin. Invest. |volume=114 |issue=10 |pages=1414–7 |year=2004 |pmid=15545992 |doi=10.1172/JCI200423586] [cite journal |author=Delarue J, Magnan C |title=Free fatty acids and insulin resistance |journal=Current opinion in clinical nutrition and metabolic care |volume=10 |issue=2 |pages=142–8 |year=2007 |pmid=17285001 |doi=10.1097/MCO.0b013e328042ba90]It is named for
Philip Randle , who described it in 1963. [cite journal |author=Randle PJ, Garland PB, Hales CN, Newsholme EA |title=The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus |journal=Lancet |volume=1 |issue= |pages=785–9 |year=1963 |pmid=13990765 |doi=]References
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