Chembox new
ImageFile = pterin structure.png ImageSize = 200px
IUPACName = 2-amino-1H-pteridin-4-one
OtherNames =Pteridoxamine
Section1 = Chembox Identifiers
CASNo = 2236-60-4
PubChem = 73000
SMILES = C1=CN=C2C(=N1)C(=O)N=C(N2)N

Section2 = Chembox Properties
MolarMass = 163.137
Appearance =
Density =
MeltingPt =
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Section3 = Chembox Hazards
MainHazards =
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Pterin is a heterocyclic compound composed of a pyrazine ring and a pyrimidine ring (a pteridine ring system); the pyrimidine ring has a carbonyl oxygen and an amino group. Several tautomers of pterin exist and are shown below. As a group, "pterins" are compounds that are derivatives of 2-amino-4-oxopteridine, with additional functional groups attached to the pyrazine ring.

Pterins were first discovered in the pigments of butterfly wings (hence the origin of their name, from the Greek "pteron", wing) and perform many roles in coloration in the biological world. Pterins also function as cofactors in enzyme catalysis.

Folates are “conjugated” pteridines which contain para-aminobenzoic acid and glutamates at the 6 position on the pteridine ring. They are critical compounds in a large number of biological group transfer reactions. These folate-dependent biosynthetic reactions include transfer of methyl groups to homocystine in the S-adenosyl methionine cycle, and transfer of formyl groups to methionine to form "N"-formylmethionine in initiator tRNAs.

Tautomers of pterin


The biosynthesis of pterins begins with the molecule guanosine triphosphate (GTP); the enzyme which controls the conversion of GTP to pterin, GTP cyclohydrolase I, is found in both prokaryotes and eukaryotes.

Other pterins

Pterin can exist in many different forms in nature depending on its function. Tetrahydrobiopterin, the major unconjugated pteridine in vertebrates, is a co-factor in the hydroxylation of aromatic compounds and synthesis of nitric oxide. Molybdopterin is a substituted pteridine that binds molybdenum to give redox enzymes involved in biological hydroxylations, reduction of nitrate, and respiratory oxidation. Tetrahydromethanopterin is used in methanogenic organisms. Cyanopterin is a glycosylated version of pteridine of unknown function in cyanobacteria.

ee also

*Folic acid

External links

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