Turnip crinkle virus (TCV) repressor of minus strand synthesis H5

The TCV hairpin 5 (H5) is an RNA element found in the turnip crinkle virus. This RNA element is composed of a stem-loop that contains a large symmetrical internal loop (LSL). H5 can repress minus-strand synthesis when the 3' side of the LSL pairs with the 4 bases at the 3'-terminus of the RNA(GCCC-OH). [cite journal | last = McCormack | first = JC | coauthors = Simon AE | year = 2004 | title = Biased hypermutagenesis associated with mutations in an untranslated hairpin of an RNA virus | journal = J Virol | volume = 78 | pages = 7813–7817 | pmid = 15220455 | doi = 10.1128/JVI.78.14.7813-7817.2004] [cite journal | last = Zhang | first = G | coauthors = Zhang J, Simon AE | year = 2004 | title = Repression and derepression of minus-strand synthesis in a plus-strand RNA virus replicon | journal = J Virol | volume = 78 | pages = 7619–7633 | pmid = 15220437 | doi = 10.1128/JVI.78.14.7619-7633.2004]

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