- Small nucleolar RNA snR54
snR54 is a
non-coding RNA that is a member of the C/D class of snoRNA which contain the C box motif (UGAUGA) and D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was first identified by a computational screen followed by experimental verification [1] . This RNA guides the 2'-O-methylation of 18SrRNA . In yeast this snoRNA is found to reside in an intron of the IMD4 gene.Species distribution
This snoRNA has been identified in both yeasts and "D. melanogaster".
References
* [1] cite journal | last = Kiss | first = T | year = 2002 | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | pages = 145–148 | pmid = 12007400 | doi = 10.1016/S0092-8674(02)00718-3
* [2] cite journal | last = Lowe | first = TM | coauthors = Eddy SR | year = 1999 | title = A computational screen for methylation guide snoRNAs in yeast | journal = Science | volume = 283 | pages = 1168–1171 | pmid = 10024243 | doi = 10.1126/science.283.5405.1168External links
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* [http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/snr54_ta.php Entry for snR54 in the UMASS Amherst Yeast snoRNA database]
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