Small nucleolar RNA SNORD59

snoRNA U59 is an RNA molecule that belongs to the C/D class of snoRNA, which contain the C box motif (UGAUGA) and the D box motif (CUGA). [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. There are two closely related copies of U59, called SNORD59A and SNORD59B. They are both expressed from the intron of the host gene ATP5A. Both SNORD59A and SNORD59B target the 2'-O-methylation of 18S rRNA position A1031.cite journal | author = Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T | title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs | journal = Cell | volume = 85 | issue = 7 | pages = 1077–88 | year = 1996 | pmid = 8674114 | doi = 10.1016/S0092-8674(00)81308-2 ] This RNA has been identified in both the human and mouse genomes. Not to be confused with the plant snoRNA U59.

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U59A | U59A entry in snoRNABase]
* [http://www-snorna.biotoul.fr/plus.php?id=U59B | U59B entry in snoRNABase]