Small nucleolar RNA SNORD46

snoRNA U46 (also known as SNORD46) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U46 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

U46 is encoded in intron 2 of the ribosomal protein S8 gene in human, and is hypothesised to guide methylation of 2'-O-ribose residues on 28S ribosomal RNA (rRNA) cite journal | last = Nicoloso | first = M | coauthors = Qu LH, Michot B, Bachellerie JP | year = 1996 | title = Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs | journal = J Mol Biol | volume = 260 | pages = 178–195 | pmid = 8764399 | doi = 10.1006/jmbi.1996.0391] cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 ] . The homologue of this snoRNA in "Arabidopsis thaliana" is called snoZ153 cite journal | last = Chen | first = CL | coauthors = Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH | year = 2003 | title = The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa | journal = Nucleic Acids Res | volume = 31 | pages = 2601–2613 | pmid = 12736310 | doi = 10.1093/nar/gkg373] . It should be noted that some human U40 sequence has been annotated in the sequence databases (Genbank) as U46.

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U46 snoRNABase entry for SNORD46]