- Small nucleolar RNA SNORD16
snoRNA U16 (also known as SNORD16) is a
non-coding RNA (ncRNA) molecule which functions in the modification of othersmall nuclear RNA s (snRNAs). This type of modifiying RNA is usually located in thenucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA U16 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-
methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .U81 i spredicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A484 cite journal | author = Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T | title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs | journal = Cell | volume = 85 | issue = 7 | pages = 1077–88 | year = 1996 | pmid = 8674114 | doi = | issn = ] and is encoded within an
intron of the gene forribosomal protein s L1 in animals cite journal | author = Fragapane P, Prislei S, Michienzi A, Caffarelli E, Bozzoni I | title = A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA | journal = EMBO J. | volume = 12 | issue = 7 | pages = 2921–8 | year = 1993 | pmid = 8335006 | doi = | issn = ] . This snoRNA was independently named MBII-98 in mouse cite journal | author = Hüttenhofer A, Kiefmann M, Meier-Ewert S, "et al" | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = EMBO J. | volume = 20 | issue = 11 | pages = 2943–53 | year = 2001 | pmid = 11387227 | doi = 10.1093/emboj/20.11.2943 | issn = ] .References
External links
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* [http://www-snorna.biotoul.fr/plus.php?id=U16 snoRNABase entry for SNORD16]
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