Small nucleolar RNA SNORA75

U23 belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs [3] . Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA (SL RNA) as possibly other, still unknown cellular RNAs [3] . U23 can direct the pseudouridylation of U97 in human 18S rRNA. U23 is encoded within intron 12 of the nucleolin gene in human, mouse, rat chicken, and Xenopus laevis.

References

* [1] cite journal | last = Ganot | first = P | coauthors = Caizergues-Ferrer M, Kiss T | year = 1997 | title = The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation | journal = Genes Dev | volume = 11 | pages = 941–956 | pmid = 9106664 | doi = 10.1101/gad.11.7.941
* [2] cite journal | last = Bachellerie | first = JP | coauthors = Cavaille J, Huttenhofer A | year = 2002 | title = The expanding snoRNA world | journal = Biochimie | volume = 84 | pages = 775–790 | pmid = 12457565 | doi = 10.1016/S0300-9084(02)01402-5
* [3] cite journal | last = Kiss | first = T | year = 2002 | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | pages = 145–148 | pmid = 12007400 | doi = 10.1016/S0092-8674(02)00718-3

External links

*