Small nucleolar RNA snoR9

snoR9 is a non-coding RNA (ncRNA) which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

R9 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs cite journal | author = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol. Cell. Biol. | volume = 22 | issue = 19 | pages = 6663–8 | year = 2002 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002 ] .

This snoRNA was identified in a computational search for GC-rich regions in the AT-rich genomes of hyperthermophiles cite journal | author = Klein RJ, Misulovin Z, Eddy SR | title = Noncoding RNA genes identified in AT-rich hyperthermophiles | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7542–7 | year = 2002 | pmid = 12032319 | doi = 10.1073/pnas.112063799 ] . This snoRNA is not related to the plant snoRNA snoR9.

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