Small nucleolar RNA snR55/Z10

Small nucleolar RNA snR55/Z10 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifiying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

snoRNA snR55 was identified in ("Schizosaccharomyces pombe") and has also been called snoRNA Z10 cite journal |author=Lowe TM, Eddy SR |title=A computational screen for methylation guide snoRNAs in yeast |journal=Science |volume=283 |issue=5405 |pages=1168–71 |year=1999 |pmid=10024243 |doi= 10.1126/science.283.5405.1168] . This snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

This predicted snoRNA does not appear to have the C/D box snoRNA terminal stem structure.

References

External links

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* [http://people.biochem.umass.edu/fournierlab/snornadb/main.php yeast snoRNA database]