Iron response element

Iron response element

The Iron response element or Iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (Untranslated Regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the ferritin mRNA IRE leading to translation repression. Binding of multiple IREs in the 3' and 5' UTRs of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability. These two activities form the basis of iron homeostasis in the vertebrate cell.

References

*

External links

*

* [http://mrna.otago.ac.nz/cgi-bin/tt_data_browse/RNAMotif?PatID=T0102 Transterm page for Iron Responsive Element]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Iron Response Element — Stäbchenmodell eines Teils von Ferritin mRNA nach PDB 2IPY (gelb: IRE) …   Deutsch Wikipedia

  • Cis-regulatory element — A cis regulatory element or cis element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA (often a chromosome). This term is constructed from the Latin word cis, which means on the same side as …   Wikipedia

  • Iron fertilization — For information on ocean fertilization schemes not involving iron, see ocean nourishment. An oceanic phytoplankton bloom in the South Atlantic Ocean, off the coast of Argentina covering an area about 300 miles (480 km) by 50 miles Iron… …   Wikipedia

  • Iron Guard death squads — The Decemviri and Nicadori, along with Codreanu, were exhumed and given a lavish burial service in November 1940. During the 1930s, three notable death squads emerged from Romania s Iron Guard: the Nicadori, the Decemviri, and the Răzbunători.… …   Wikipedia

  • Human iron metabolism — is the set of chemical reactions maintaining human homeostasis of iron. Iron is an essential element for most life on Earth, including human beings. The control of this necessary but potentially toxic substance is an important part of many… …   Wikipedia

  • Rare earth element — Rare earth ore, shown with a United States penny for size comparison These rare …   Wikipedia

  • IRE — steht für: die Einzahl von Iren Irē, den livischen Namen für den lettischen Ort Mazirbe Die Abkürzung IRE steht für: Iron Response Element (Zellbiologie) Interregio Express, ein Produkt des deutschen Schienenpersonennahverkehrs Institute of Radio …   Deutsch Wikipedia

  • Copper in health — Normal absorption and distribution of copper. Cu = copper, CP = ceruloplasmin, green = ATP7B carrying copper. Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms). In… …   Wikipedia

  • DMT1 — Solute carrier family 11 (proton coupled divalent metal ion transporters), member 2 Available structures PDB …   Wikipedia

  • NFE2L2 — Nuclear factor (erythroid derived 2) like 2 Identifiers Symbols NFE2L2; NRF2 External IDs …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”