Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)

Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)

The heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) is an RNA element that allows cap independent translation during conditions such as heat shock and stress. It has been shown that the 216 nucleotide long 5' UTR contains internal ribosome entry site activity. [cite journal | last = Rubtsova | first = MP | coauthors = Sizova DV, Dmitriev SE, Ivanov DS, Prassolov VS, Shatsky IN | year = 2003 | title = Distinctive properties of the 5'-untranslated region of human hsp70 mRNA | journal = J Biol Chem | volume = 278 | pages = 22350–22356 | pmid = 12682055 | doi = 10.1074/jbc.M303213200]

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