Flavivirus 3' UTR cis-acting replication element (CRE)

The Flavivirus 3' UTR cis-acting replication element (CRE) is an RNA element that is thought to play a crucial role in replication and is thought to be needed for the formation of a "replication complex". [cite journal | last = Zeng | first = L | coauthors = Falgout B, Markoff L | year = 1998 | title = Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replication | journal = J Virol | volume = 72 | pages = 7510–7522 | pmid = 9696848] Although evidence has been presented for an existence of a pseudoknot structure in this RNA, [cite journal | last = Shi | first = PY | coauthors = Brinton MA, Veal JM, Zhong YY, Wilson WD | year = 1996 | title = Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA | journal = Biochemistry | volume = 35 | pages = 4222–4230 | pmid = 8672458 | doi = 10.1021/bi952398v] it does not appear to be well conserved across flaviviruses. Deletions of the 3' UTR of flaviviruses have been shown to be lethal for infectious clones.

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