Connexin-32 internal ribosome entry site (IRES)

Connexin-32 internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Cx32
Identifiers
Symbol	IRES_Cx32
Rfam	RF00484
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	0043022
SO	0000243

The connexin-32 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of connexin-32 and allows cap-independent translation. This internal ribosome entry site (IRES) allows cap independent translation during conditions such as heat shock and stress.^[1]

References

1. ^ Hudder, A; Werner R (2000). "Analysis of a Charcot-Marie-Tooth disease mutation reveals an essential internal ribosome entry site element in the connexin-32 gene". J Biol Chem 275 (44): 34586–34591. doi:10.1074/jbc.M005199200. PMID 10931843. 

External links

• Rfam page for Connexin-32 internal ribosome entry site (IRES)