Ciliate telomerase RNA

Ciliate telomerase RNA

Telomerase is a ribonucleoprotein reverse transcriptase that synthesises telomeric DNA. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence. [cite journal | last = McCormick-Graham | first = M | coauthors = Romero DP | year = 1995 | title = Ciliate telomerase RNA structural features | journal = Nucleic Acids Res | volume = 23 | pages = 1091–1097 | pmid = 7739888 | doi = 10.1093/nar/23.7.1091] [cite journal | last = Lingner | first = J | coauthors = Hendrick LL, Cech TR | year = 1994 | title = Telomerase RNAs of different ciliates have a common secondary structure and a permuted template | journal = Genes Dev | volume = 8 | pages = 1984–1998 | pmid = 7958872 | doi = 10.1101/gad.8.16.1984] cite journal | author = Theimer CA, Feigon J | title = Structure and function of telomerase RNA | journal = Curr. Opin. Struct. Biol. | volume = 16 | issue = 3 | pages = 307–18 | year = 2006 | pmid = 16713250 | doi = 10.1016/j.sbi.2006.05.005 ]

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