Bag-1 internal ribosome entry site (IRES)

Bag-1 internal ribosome entry site (IRES)

The bag-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. Its effects apoptosis through IRES mediated translation of the BAG-1 protein.

When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although bag-1 translation usually occurs via a cap-dependent mechanism it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised cite journal | author = Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE | title = The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock | journal = Oncogene | volume = 20 | issue = 30 | pages = 4095–100 | year = 2001 | pmid = 11494137 | doi = 10.1038/sj.onc.1204547 | issn = ] .

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