Surfactant protein C

Surfactant protein C

Pfam_box
Symbol = Pulm_surfact_AP
Name = Surfactant-associated polypeptide


width =
caption =
Pfam=
InterPro= IPR001729
SMART= SF_P
PROSITE = PDOC00298
SCOP =
TCDB =
OPM family=
OPM protein=
PDB=PDB3|1spf :1-35

Pfam_box
Symbol = SP_C-Propep
Name = Surfactant protein C, N terminal propeptide


width =
caption =
Pfam= PF08999
InterPro= IPR015091
SMART=
Prosite =
SCOP =
TCDB =
OPM family=
OPM protein= 1spf
PDB=PDB3|1spf :1-35

protein
Name=surfactant, pulmonary-associated protein C
caption=


width=
HGNCid=10802
Symbol=SFTPC
AltSymbols=SFTP2
EntrezGene=6440
OMIM=178620
RefSeq=NM_003018
UniProt=P11686
PDB=
ECnumber=
Chromosome=8
Arm=p
Band=21
LocusSupplementaryData=

The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. Its main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptidecite journal |author=Li J, Jornvall H, Johansson J, Curstedt T, Liepinsh E, Almlen A, Thyberg J |title=Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C |journal=FEBS J |volume=273 |issue=5 |pages=- |year=2006 |pmid=16478467 |doi=10.1111/j.1742-4658.2006.05124.x] .

References

ee also

* pulmonary surfactant

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Surfactant protein D — Surfactant, pulmonary associated protein D, also known as SFTPD, is is a collectin.cite web | title = Entrez Gene: SFTPD surfactant, pulmonary associated protein D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Surfactant protein A — protein Name=surfactant, pulmonary associated protein A1 caption= width= HGNCid=10798 Symbol=SFTPA1 AltSymbols=SFTP1 EntrezGene=6435 OMIM=178630 RefSeq=NM 005411 UniProt=Q8IWL2 PDB= ECnumber= Chromosome=10 Arm=q Band=22.3… …   Wikipedia

  • Surfactant protein B — protein Name=surfactant, pulmonary associated protein B caption= width= HGNCid=10801 Symbol=SFTPB AltSymbols=SFTP3 EntrezGene=6439 OMIM=178640 RefSeq=NM 000542 UniProt=P07988 PDB= ECnumber= Chromosome=2 Arm=p Band=12 LocusSupplementaryData=… …   Wikipedia

  • Surfactant — ist ein englisches Kunstwort (surface active agent) und bedeutet „grenzflächenaktive Substanz“. Die englische Bezeichnung hat sich im Deutschen für eine spezielle, bedeutsame oberflächenaktive Substanz in der Lunge durchgesetzt. Von… …   Deutsch Wikipedia

  • Surfactant metabolism dysfunction — is a condition where pulmonary surfactant is insufficient for adequate respiration. Types include: Type OMIM Gene Locus SMDP1 265120 SFTPB 2p12 SMDP2 610913 SPTPC 8p21 SMDP3 …   Wikipedia

  • Pulmonary surfactant-associated protein B — Surfactant, pulmonary associated protein B, also known as SFTPB, is a human gene.cite web | title = Entrez Gene: SFTPB surfactant, pulmonary associated protein B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Pulmonary surfactant-associated protein C — Surfactant, pulmonary associated protein C, also known as SFTPC, is a human gene.cite web | title = Entrez Gene: SFTPC surfactant, pulmonary associated protein C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Protein — A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. Proteins are required for the structure, function, and regulation of the body s… …   Medical dictionary

  • Surfactant — A fluid secreted by the cells of the alveoli (the tiny air sacs in the lungs) that serves to reduce the surface tension of pulmonary fluids; surfactant contributes to the elastic properties of pulmonary tissue. In more technical terms, a… …   Medical dictionary

  • surfactant — n. a wetting agent. Pulmonary surfactant, secreted by type II pneumocytes, is a complex mixture of compounds (including lipids, protein, and carbohydrates) that prevents the air sacs (alveoli) of the lungs from collapsing by reducing surface… …   The new mediacal dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”