Surfactant protein C

Surfactant protein C

Pfam_box
Symbol = Pulm_surfact_AP
Name = Surfactant-associated polypeptide


width =
caption =
Pfam=
InterPro= IPR001729
SMART= SF_P
PROSITE = PDOC00298
SCOP =
TCDB =
OPM family=
OPM protein=
PDB=PDB3|1spf :1-35

Pfam_box
Symbol = SP_C-Propep
Name = Surfactant protein C, N terminal propeptide


width =
caption =
Pfam= PF08999
InterPro= IPR015091
SMART=
Prosite =
SCOP =
TCDB =
OPM family=
OPM protein= 1spf
PDB=PDB3|1spf :1-35

protein
Name=surfactant, pulmonary-associated protein C
caption=


width=
HGNCid=10802
Symbol=SFTPC
AltSymbols=SFTP2
EntrezGene=6440
OMIM=178620
RefSeq=NM_003018
UniProt=P11686
PDB=
ECnumber=
Chromosome=8
Arm=p
Band=21
LocusSupplementaryData=

The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. Its main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptidecite journal |author=Li J, Jornvall H, Johansson J, Curstedt T, Liepinsh E, Almlen A, Thyberg J |title=Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C |journal=FEBS J |volume=273 |issue=5 |pages=- |year=2006 |pmid=16478467 |doi=10.1111/j.1742-4658.2006.05124.x] .

References

ee also

* pulmonary surfactant

External links

*


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