Bergmann degradation

Bergmann degradation

The Bergmann degradation is series of chemical reactions designed to remove a single amino acid from the carboxylic acid end of a peptide. [Bergmann, M. "Science" 1934, "79", 439.] [Bergmann, M.; Zervas, L. "J. Biol. Chem." 1936, "113", 341.]

The acyl azide of a peptide (1) undergoes a Curtius rearrangement in the presence of benzyl alcohol (2) to give a benzyl carbamate (3). The Cbz group of intermediate 3 is removed by hydrogenolysis to give an unsubstituted amide (4) and an aldehyde (5).

References

ee also

*Curtius rearrangement
*Edman degradation


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Edman degradation — Edman degradation, developed by Pehr Edman, is a method of sequencing amino acids in a peptide. [Edman, P. Acta Chem. Scand. 1950, 4 , 283.] In this method, the amino terminal residue is labeled and cleaved from the peptide without disrupting the …   Wikipedia

  • List of organic reactions — Well known reactions and reagents in organic chemistry include Contents: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z    See also   Ext …   Wikipedia

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • Mdm2 — Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) Estructura tridimensional de la proteína Mdm2. HUGO 6973 …   Wikipedia Español

  • MÉTABOLISME — Rien ne se crée, rien ne se perd. Le principe de conservation de l’énergie et de la matière ne souffre aucune exception. Aussi les êtres vivants ne sont ils que des transformateurs d’énergie: ils reçoivent du dehors de l’énergie chimique et ils… …   Encyclopédie Universelle

  • Scientific phenomena named after people — This is a list of scientific phenomena and concepts named after people (eponymous phenomena). For other lists of eponyms, see eponym. NOTOC A* Abderhalden ninhydrin reaction Emil Abderhalden * Abney effect, Abney s law of additivity William de… …   Wikipedia

  • Список научных публикаций Альберта Эйнштейна — Альберт Эйнштейн (1879 1955) был известным специалистом по теоретической физике, который наиболее известен как разработчик общей и специальной теорий относительности. Он также внёс большой вклад в развитие статистической механики, особенно… …   Википедия

  • Cathepsin — A cathepsin (Union of two Greek words, kata :down and hepsein:boil) is a cysteine or aspartic protease, a type of protein that breaks apart other proteins, found in many types of cells including those in all animals. There are approximately a… …   Wikipedia

  • Koala — Pour les articles homonymes, voir Koala (homonymie). Phascolarctos cinereus …   Wikipédia en Français

  • 3-Methylcholanthren — Strukturformel Allgemeines Name 3 Methylcholanthren …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”