- Triple bolus test
A triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's
pituitaryfunction. Three hormones (usually synthetic analogues) are injected as a bolus into the patient's vein to stimulate the anterior pituitarygland: insulin, gonadotropin-releasing hormone(GnRH), and thyrotropin-releasing hormone(TRH). The gland's response is assessed by measuring cortisol, growth hormone(GH), prolactin, thyroid-stimulating hormone(TSH), luteinizing hormone(LH) and follicle-stimulating hormone(FSH) hormone levels. Blood glucoselevels are also monitored for hypoglycemia. A triple bolus test is usually ordered and interpreted by endocrinologists.
The triple bolus test was introduced in 1973 by physicians from the London
Royal PostgraduateMedical Schooland Queen Elizabeth Hospital, Birmingham. [cite journal |author=Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR |title=Combined test for assessment of anterior pituitary function |journal=Br Med J |volume=4 |issue=5888 |pages=326–9 |year=1973 |month=November |pmid=4202260 |pmc=1587416] It followed earlier reports combining insulin and vasopressinanalogues in the diagnosis of hypopituitarism. [cite journal |author=Greenwood FC, Landon J |title=Assessment of hypothalamic pituitary function in endocrine disease |journal=J. Clin. Pathol. |volume=19 |issue=3 |pages=284–92 |year=1966 |month=May |pmid=4287115 |pmc=473256 |doi= |url=http://jcp.bmj.com/cgi/reprint/19/3/284]
Insulin tolerance test
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