RNase MRP

RNase MRP

RNase MRP is an enzymatically active ribonucleoprotein with two distinct roles in eukaryotes. In mitochondria it plays a direct role in the initiation of mitochondrial DNA replication. In the nucleus it is involved in precursor rRNA processing, where it cleaves the internal transcribed spacer 1 between 18S and 5.8S rRNAs. Despite distinct functions, RNase MRP has been shown to be evolutionarily related to RNase P. Like eukaryotic RNase P, RNase MRP is not catalytically active without associated protein subunits.

References

* [1] cite journal | last = Schmitt | first = ME | coauthors = Bennett JL, Dairaghi DJ, Clayton DA | year = 1993 | title = Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison | journal = FASEB J | volume = 7 | pages = 208–213 | pmid = 7678563
* [2] cite journal | last = Li | first = X | coauthors = Frank DN, Pace N, Zengel JM, Lindahl L | year = 2002 | title = Phylogenetic analysis of the structure of RNase MRP RNA in yeasts | journal = RNA | volume = 8 | pages = 740–751 | pmid = 12088147 | doi = 10.1017/S1355838202022082
* [3] cite journal | last = Kiss | first = T | coauthors = Marshallsay C, Filipowicz W | year = 1992 | title = 7-2/MRP RNAs in plant and mammalian cells: association with higher order structures in the nucleolus | journal = EMBO J | volume = 11 | pages = 3737–3746 | pmid = 1382978

External links

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