Mannose-6-phosphate

Mannose-6-phosphate

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ImageFile=Mannose-6-phosphate.svg
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IUPACName=
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Section1= Chembox Identifiers
CASNo=3672-15-9
PubChem=65127
SMILES=C(C1C(C(C(C(O1)O)O)O)O)OP(=O)(O)O
MeSHName=mannose-6-phosphate
Section2= Chembox Properties
Formula=C6H13O9P
MolarMass=260.136 g/mol
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Density=
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Section3= Chembox Hazards
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Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase.

M6P is a targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the "cis"-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme UDP-N-acetylglucosamine:N-acetylglucosaminyl-1-phosphotransferase catalyzes the "N"-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the "trans"-Golgi. There, the M6P moiety is recognized by mannose 6-phosphate receptor (MPR) proteins.

The MPRs traffic in vesicles to the lysosome via an endosome.

ee also

* insulin-like growth factor 2 receptor
* mannose

External links

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