Augustus d'Este

Infobox British Royalty|none
name =Augustus d'Este
royal house =House of Hanover
father =Prince Augustus Frederick, Duke of Sussex
mother =Lady Augusta Murray
date of birth =birth date|1794|1|13|df=yes
place of birth =London, Great Britain
date of death =death date and age|1848|12|28|1794|1|13|df=yes
place of death =Ramsgate, Kent|

Augustus Frederick d'Este (1794-1848) was the son of Prince Augustus Frederick, Duke of Sussex and Lady Augusta Murray and the grandson of George III. His parents marriage was in contravention of the Royal Marriages Act 1772, which meant that Augustus d'Este was legally considered illegitimate.

Augustus d’Este is the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made [cite | author = Alastair Compston et al | title = McAlpine's Multiple Sclerosis 4th ed.| publisher = Churchill Livingstone | date = 2005] . The course of his MS, which was not diagnosed during his lifetime, is known from the diaries he kept. D'Este left a detailed diary describing his 22 years living with the disease. He began his diary in 1822 and it had its last entry in 1846; only to remain unknown until 1948. [cite book |last= Firth|first=D |title= The Case of August D`Esté|year=1948 |publisher=Cambridge University Press |location=Cambridge]

His symptoms began at age 28 with a sudden transient visual loss after the funeral of a friend. During the course of his disease he developed weakness of the legs, clumsiness of the hands, numbness, dizziness, bladder disturbances, and erectile dysfunction. By 1843 he was experiencing persistent symptoms including tremor and nocturnal spasms and in 1844, he began to use a wheelchair. His last years became confined to his bed. Despite his illness, he kept an optimistic view of life.

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